HOW Y-CHROMOSOMES BECOME GENETICALLY INERT

被引：87

作者：

STEINEMANN, M

STEINEMANN, S

LOTTSPEICH, F

机构：

[1] UNIV MUNICH,INST GENET & MIKROBIOL,W-8000 MUNICH 19,GERMANY

[2] MAX PLANCK INST BIOCHEM,GENEZENTRUM,W-8033 MARTINSRIED,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 12期

关键词：

CHROMOSOME STRUCTURE; DROSOPHILA-MIRANDA; SILENCED LCP GENES; RETROTRANSPOSONS; Y-CHROMOSOME DEGENERATION;

D O I：

10.1073/pnas.90.12.5737

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have investigated the mechanistic aspects of inactivation of the major larval cuticle protein genes (Lcp1-4) in Drosophila miranda during Y chromosome evolution. The Lcp genes are located on the X2 and neo-Y chromosomes in D. miranda but are autosomally inherited in all other Drosophila species investigated so far. In the neo-Y chromosome all four Lcp loci are embedded within a dense cluster of transposable elements. The X2 Lcp1-4 loci are expressed, while the Y chromosomal Lcp3 locus shows only reduced activity and the Lcp1, Lcp2, and Lcp4 are completely inactive. Our results suggest that Lcp1 and Lcp3 loci on the degenerating Y chromosome of D. miranda are silenced by neighboring transposable elements. These observations support our assumption that the first step in Y chromosome degeneration is the successive silencing of Y chromosomal loci caused by trapping and accumulation of transposons.

引用

页码：5737 / 5741

页数：5

共 30 条

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