GLUTATHIONE INHIBITS REPLICATION AND EXPRESSION OF VIRAL-PROTEINS IN CULTURED-CELLS INFECTED WITH SENDAI VIRUS

被引：44

作者：

GARACI, E ^{[1
]}

PALAMARA, AT ^{[1
]}

DIFRANCESCO, P ^{[1
]}

FAVALLI, C ^{[1
]}

CIRIOLO, MR ^{[1
]}

ROTILIO, G ^{[1
]}

机构：

[1] UNIV ROME TOR VERGATA,DEPT BIOL,I-00173 ROME,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91343-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH of viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein. © 1992.

引用

页码：1090 / 1096

页数：7

共 21 条

[1] SUPPRESSION OF VIRUS-REPLICATION BY PROSTAGLANDIN-A IS ASSOCIATED WITH HEAT-SHOCK PROTEIN-SYNTHESIS [J].