RELATIONSHIP BETWEEN SEROTONERGIC MEASURES IN PERIPHERY AND THE BRAIN OF MOUSE

被引：42

作者：

PIETRASZEK, MH ^{[1
]}

TAKADA, Y ^{[1
]}

YAN, D ^{[1
]}

URANO, T ^{[1
]}

SERIZAWA, K ^{[1
]}

TAKADA, A ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, DEPT PHYSIOL, HAMAMATSU, SHIZUOKA 43131, JAPAN

来源：

LIFE SCIENCES | 1992年 / 51卷 / 01期

关键词：

D O I：

10.1016/0024-3205(92)90221-A

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Circadian rhythm and the relationship between the concentration of serotonin (5HT) and related substances (5-hydroxyindoleacetic acid ; 5HIAA and tryptophan ; Trp ) in mouse brain, stomach and blood have been studied. All factors underwent circadian changes in the brain and blood. 5HT and 5HIAA levels in the stomach showed no circadian fluctuation. The concentrations of 5HT in the brain and blood did not correlate. Significant correlations were found between other serotonergic parameters analyzed in brain, stomach and blood. A significant negative correlation was observed between brain 5HIAA and blood 5HIAA. The concentration of tryptophan in the brain was correlated with the plasma total tryptophan level . There was fairly significant correlation (p < 0.06) between brain serotonin and plasma tryptophan levels . The brain serotonin and tryptophan levels were strongly correlated (R = 0.410, p < 0.03). Significant negative correlation was found between serotonin in the blood and serotonin in the stomach as well as between its level in the brain and in the stomach. The significance of these findings and their relationship to the use of peripheral serotonergic system as a model of neurons are discussed.

引用

页码：75 / 82

页数：8

共 27 条

[1]

ALBRECHT P, 1956, P SOC EXP BIOL MED, V92, P703

[2]

ANDERSON GM, 1981, CLIN CHEM, V27, P775

[3]

BERTACCINI BG, 1960, J PHYSIOL-LONDON, V153, P239

[4] SUBSTRATE SPECIFICITY OF STEADY-STATE AMINO ACID TRANSPORT IN MOUSE BRAIN SLICES [J].

BLASBERG, R ;

LAJTHA, A .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1965, 112 (02) :361-&

[5]

BOURNE HR, 1968, LANCET, V2, P895

[6] TRITIATED IMIPRAMINE BINDING-SITES ARE DECREASED IN PLATELETS OF UNTREATED DEPRESSED-PATIENTS [J].

BRILEY, MS ;

LANGER, SZ ;

RAISMAN, R ;

SECHTER, D ;

ZARIFIAN, E .

SCIENCE, 1980, 209 (4453) :303-305

[7]

BUCZKO W, 1984, THROMB HAEMOSTASIS, V51, P131

[8]

DIXIT BALWANT N., 1967, LIFE SCI, V6, P755, DOI 10.1016/0024-3205(67)90132-4

[9]

DOUGLAS WW, 1985, PHARMACOL BASIS THER, P628

[10] CIRCADIAN-RHYTHM IN BLOOD AND BRAIN BIOGENIC-AMINES AND OTHER BIOCHEMICAL CHANGES IN RABBITS [J].

ELEFTHERIOU, BE .

BRAIN RESEARCH, 1974, 75 (01) :145-152

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