A PUTATIVE SIROLIMUS (RAPAMYCIN) EFFECTOR PROTEIN

被引:56
作者
CHEN, YQ
CHEN, HH
RHOAD, AE
WARNER, L
CAGGIANO, TJ
FAILLI, A
ZHANG, HZ
HSIAO, CL
NAKANISHI, K
MOLNARKIMBER, KL
机构
[1] WYETH AYERST RES,DIV INFLAMMATORY DIS,PRINCETON,NJ 08543
[2] WYETH AYERST RES,DIV CHEM SCI,PRINCETON,NJ 08543
[3] WYETH AYERST RES,STRUCT BIOL,PHILADELPHIA,PA
关键词
D O I
10.1006/bbrc.1994.2140
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sirolimus (rapamycin), a new immunosuppressive drug, inhibits proliferation of a wide spectrum of T and B cells. The immunosuppressive mechanism of sirolimus is still unclear. We recently isolated a membrane associated protein with an apparent molecular weight of 210 kDa, p210, from cultured Molt 4 cells and BJAB cells and from normal human T cells using an affinity matrix method. The p210 binds to sirolimus:FKBP12 complex, but only at background levels to FKBP12 alone, to FK506:FKBP12 complex, or sirolimus-biotin alone. Among the sirolimus analogs tested, the binding ability of p210 to drug:FKBP12 complexes correlates with the immunosuppressive activity of the drugs, suggesting that p210 is the sirolimus effector protein. (C) 1994 Academic Press, Inc.
引用
收藏
页码:1 / 7
页数:7
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