The Eulerian cosmological fluid equations are used to study the nonlinear mode coupling of density fluctuations. We evaluate the second-order power spectrum including all four-point contributions. In the weakly nonlinear regime we find that the dominant nonlinear contribution for realistic cosmological spectra is made by the coupling of long-wave modes and is well estimated by second-order perturbation theory. For a linear spectrum like that of the cold dark matter model, second-order effects cause a significant enhancement of the high-k part of the spectrum and a slight suppression at low k near the peak of the spectrum. Our perturbative results agree well in the quasi-linear regime with the nonlinear spectrum from high-resolution N-body simulations. We find that due to the long-wave mode coupling, characteristic nonlinear masses grow less slowly in time (i.e., are larger at higher redshifts) than would be estimated using the linear power spectrum. For the cold dark matter model at (I + z) = (20, 10, 5, 2) the nonlinear mass is about (180, 8, 2.5, 1.6) times (respectively) larger than a linear extrapolation would indicate, if the condition rms deltarho/rho = 1 is used to define the nonlinear scale. At high redshift the Press-Schechter mass distribution significantly underestimates the abundance of high-mass objects for the cold dark matter model. Although the quantitative results depend on the definition of the nonlinear scale, these basic consequences hold for any initial spectrum whose postrecombination spectral index n decreases sufficiently rapidly with increasing k, a feature that arises quite generally during the transition from a radiation- to matter-dominated universe.