ONLINE TRACE ENRICHMENT OF MIFENTIDINE IN PLASMA USING COLUMN-SWITCHING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：5

作者：

JANG, WC

LEE, HS

机构：

[1] Screening & Toxicology Research Center, Korea Research Institute of Chemical Technology, Daedeog Danji, Taejeon, 305-606

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 06期

关键词：

D O I：

10.1080/10826079408013770

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to develop for the determination of mifentidine, a new long-acting histamine H-2 receptor antagonist,in plasma using a column-switching HPLC with a ultraviolet (UV) detection. Changing the pH influenced the species equilibria of mifentidine and these were well monitored and quantitated. This method showed a excellent precision with good sensitivity and speed, and a detection limit of 10 ng/mL. The total analysis time per sample was less than 20 min and mean coefficients of variation for intra- and inter- assay were both less than 3 %. The method has been successfully applied to plasma samples from rats receiving oral administration of mifentidine.

引用

页码：1375 / 1384

页数：10

共 11 条

[1] PHARMACOLOGICAL PROFILE OF MIFENTIDINE - A NOVEL H-2-RECEPTOR ANTAGONIST [J].

GIACHETTI, A ;

PAGANI, F ;

MICHELETTI, R ;

BRAMBILLA, A ;

CEREDA, E ;

DONETTI, A .

AGENTS AND ACTIONS, 1985, 16 (3-4) :173-175

[2] STUDIES ON THE ACTIVE MOLECULAR-SPECIES OF THE H2 RECEPTOR ANTAGONISTS CIMETIDINE AND MIFENTIDINE [J].

HAAKSMA, EEJ ;

RADEMAKER, B ;

KRAMER, K ;

ERIKS, JC ;

BAST, A ;

TIMMERMAN, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (01) :208-211

[3] PHARMACOKINETICS OF MIFENTIDINE AFTER SINGLE AND MULTIPLE ORAL-ADMINISTRATION TO HEALTHY-VOLUNTEERS [J].

IMBIMBO, BP ;

URSO, R ;

THIEME, G ;

STURN, B ;

UECKERT, B ;

VIDI, A ;

LADINSKY, H ;

DANIOTTI, S .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 26 (04) :407-413

[4]

JAHANSHAHI M, 1992, J CHROMATOGR, V575, P75

[5] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF DICLOFENAC SODIUM IN PLASMA USING COLUMN-SWITCHING TECHNIQUE FOR SAMPLE CLEANUP [J].

LEE, HS ;

KIM, EJ ;

ZEE, OP ;

LEE, YJ .

ARCHIV DER PHARMAZIE, 1989, 322 (11) :801-806

[6] COLUMN-SWITCHING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CIPROFLOXACIN IN SERUM USING AMBERLITE XAD-7 [J].

LEE, HS ;

ZEE, OP ;

WOO, BH ;

LEE, YJ .

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL, 1991, 26 (07) :1253-1265

[7] SIMULTANEOUS DETERMINATION OF CEFAMANDOLE AND CEFAMANDOLE NAFATE IN HUMAN PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH COLUMN SWITCHING [J].

LEE, HS ;

ZEE, OP ;

KWON, KI .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 528 (02) :425-433

[8] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF RIFAPENTINE IN SERUM USING COLUMN SWITCHING [J].

LEE, HS ;

SHIN, HC ;

HAN, SS ;

ROH, JK .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 574 (01) :175-178

[9] SIMULTANEOUS DETERMINATION OF CEFOXITIN, CEFUROXIME, CEPHALEXIN AND CEPHALORIDINE IN PLASMA USING HPLC AND A COLUMN-SWITCHING TECHNIQUE [J].

LEE, YJ ;

LEE, HS .

CHROMATOGRAPHIA, 1990, 30 (1-2) :80-84

[10] A SIMPLE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PRECOLUMN TECHNIQUE FOR INVESTIGATION OF DRUG-METABOLISM IN BIOLOGICAL-FLUIDS [J].

VOELTER, W ;

KRONBACH, T ;

ZECH, K ;

HUBER, R .

JOURNAL OF CHROMATOGRAPHY, 1982, 239 (APR) :475-482

← 1 2 →