HEPATIC-EFFECTS OF XYLIDINE ISOMERS IN RATS

被引：8

作者：

MAGNUSSON, G ^{[1
]}

MAJEED, SK ^{[1
]}

DOWN, WH ^{[1
]}

SACHARIN, RM ^{[1
]}

JORGESON, W ^{[1
]}

机构：

[1] HUNTINGDON RES CTR, DEPT METAB & PHARMACOKINET, HUNTINGDON PE18 6ES, ENGLAND

来源：

TOXICOLOGY | 1979年 / 12卷 / 01期

关键词：

D O I：

10.1016/0300-483X(79)90033-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of repeated (4 wk) oral administration of 2,4-, 2,5- or 2,6-xylidine (at dose levels of 400-500 mg/kg per day) on the morphology and microsomal drug metabolizing enzyme activity of the liver was studied in rats. All 3 isomers caused hepatomegaly which was considered due to proliferation of the smooth endoplasmic reticulum. Decreases in glycogen content and glucose-6-phosphatase activity were demonstrated histochemically. Biochemical investigations showed increases in microsomal protein and cytochrome P-450 content in rats dosed with 2,4- or 2,5-xylidine and in glucuronyltransferase activity in rats given 2,4-, 2,5- or 2,6-xylidine. Aniline hydroxylase activity was increased in all treated rats except males dosed with 2,6-xylidine. All isomers of xylidine can be inducers of microsomal drug-metabolizing enzyme activity and they may be metabolized by oxidation; the xylidine molecule may be eliminated as a conjugate with glucuronic acid.

引用

页码：63 / 74

页数：12

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