ACUTE INTOXICATION WITH SODIUM VALPROATE

被引：56

作者：

CHADWICK, DW ^{[1
]}

CUMMING, WJK ^{[1
]}

LIVINGSTONE, I ^{[1
]}

CARTLIDGE, NEF ^{[1
]}

机构：

[1] NEWCASTLE GEN HOSP,REG NEUROL CTR,NEWCASTLE TYNE NE4 6BE,TYNE & WEAR,ENGLAND

来源：

ANNALS OF NEUROLOGY | 1979年 / 6卷 / 06期

关键词：

D O I：

10.1002/ana.410060616

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two epileptic patients developed an acute toxic encephalopathy consisting of altered behavior, deteriorating seizure control, and confusion while taking sodium valproate alone. Serum valproate levels were greater than 100 μg/ml in both. Toxic symptoms resolved when the dose of valproate was reduced, with a consequent fall in serum concentration of the drug. Copyright © 1979 American Neurological Association

引用

页码：552 / 553

页数：2

共 6 条

[1] SIDE-EFFECTS OF SODIUM VALPROATE [J].

BELLMAN, MH ;

ROSS, EM .

BRITISH MEDICAL JOURNAL, 1977, 1 (6077) :1662-1662

[2] SODIUM VALPROATE IN TREATMENT OF EPILEPSY [J].

JEAVONS, PM ;

CLARK, JE .

BRITISH MEDICAL JOURNAL, 1974, 2 (5919) :584-586

[3] VALPROIC ACID IN EPILEPSY - CLINICAL AND PHARMACOLOGICAL EFFECTS [J].

MATTSON, RH ;

CRAMER, JA ;

WILLIAMSON, PD ;

NOVELLY, RA .

ANNALS OF NEUROLOGY, 1978, 3 (01) :20-25

[4] CONTROLLED TRIAL OF SODIUM VALPROATE IN SEVERE EPILEPSY [J].

RICHENS, A ;

AHMAD, S .

BRITISH MEDICAL JOURNAL, 1975, 4 (5991) :255-256

[5] PHARMACOKINETICS OF DI-N-PROPYLACETATE IN EPILEPTIC PATIENTS [J].

SCHOBBEN, F ;

VANDERKLEIJN, E ;

GABREELS, FJM .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1975, 8 (02) :97-105

[6] SODIUM DI-N-PROPYLACETATE (DPA) IN TREATMENT OF EPILEPSY - REVIEW [J].

SIMON, D ;

PENRY, JK .

EPILEPSIA, 1975, 16 (04) :549-573

← 1 →