A PRACTICAL SYNTHESIS OF (R) AND (S) 3-HYDROXYGLUTARIC ACID MONOESTERS BY ENZYMATIC-HYDROLYSIS WITH A BACTERIAL ESTERASE

被引：18

作者：

MONTEIRO, J ^{[1
]}

BRAUN, J ^{[1
]}

LEGOFFIC, F ^{[1
]}

机构：

[1] ECOLE NATL SUPER CHIM,BIOORGAN & BIOTECHNOL,CNRS,URA 1389,11 RUE P & M CURIE,F-75231 PARIS 05,FRANCE

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 03期

关键词：

D O I：

10.1080/00397919008052771

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hemihydrolysis of diethyl 3-hydroxy- glutarate with an industrial enzyme, “Esterase 30 000”, in a biphasic system allows an efficient enantio-selective synthesis of (R) and (S) 3-hydroxyglutaric acid ethyl and t-butyl monoesters in large scale and with excellent yield. Copyright © 1990 by Taylor & Francis Group. All rights reserved.

引用

页码：315 / 319

页数：5

共 6 条

[1] A CONVERGENT SYNTHETIC STRATEGY FOR THE POLYENE MACROLIDE PIMARICIN [J].