CONFORMATIONAL STUDIES ON MUSCULAR PARVALBUMINS COOPERATIVE BINDING OF CALCIUM(II) TO PARVALBUMINS

被引：34

作者：

CAVE, A ^{[1
]}

PAGES, M ^{[1
]}

MORIN, P ^{[1
]}

DOBSON, CM ^{[1
]}

机构：

[1] INORGAN CHEM LAB,OXFORD OX1 3QR,ENGLAND

来源：

BIOCHIMIE | 1979年 / 61卷 / 5-6期

关键词：

D O I：

10.1016/S0300-9084(79)80158-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1H NMR and ORD were used to characterize the respective variations of tertiary structure and secondary structure of parvalbumins with calcium content ((Pa(O), without calcium and PaCa2 calcium saturated) and temperature. It has been observed that the tertiary structure can be lost without significant variation of the helical content. Cooperative binding of calcium to Pa(O) has been shown by NMR spectroscopy under low ionic strength conditions and at neutral pH. The present study shows that the calcium binding affinity of parvalbumin is dependent on the tertiary structure. Calcium binding and calcium release functions of parvalbumins in the muscle may be controlled by their tertiary structure. © 1979 Masson, Paris.

引用

页码：607 / 613

页数：7

共 32 条

[1]

ANDRASKO J, 1974, CHEM SCRIPTA, V6, P163

[2] DISTRIBUTION OF PARVALBUMINS IN MUSCLE AND IN OTHER TISSUES [J].