POTENTIATION OF RESPONSES OF CORTICAL-NEURONS TO 3,5-CYCLIC ADENOSINE-MONOPHOSPHATE BY DESIPRAMINE

被引：3

作者：

JONES, RSG ^{[1
]}

ROBERTS, MHT ^{[1
]}

机构：

[1] UNIV WALES UNIV COLL CARDIFF,DEPT PHYSIOL,CARDIFF CF1 1XL,S GLAMORGAN,WALES

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 8-9期

关键词：

D O I：

10.1016/0028-3908(79)90038-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Responses of cortical neurones to cyclic adenosine 3,5-monophosphate (cAMP) have been compared to responses of these neurones to noradrenaline (NA). All neurones depressed by NA were also depressed by cAMP. However, there was no such correlation between excitatory effects of the two substances. Depressant responses to cAMP and NA could be concurrently potentiated by the tricyclic antidepressant drug desipramine. It is suggested that the potentiation of responses to the two substances occurs by the same mechanism, possibly by post-synaptic inhibition of phosphodiesterase. © 1979.

引用

页码：701 / 704

页数：4

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