CYTOGENETIC FINDINGS IN 9 LEIOMYOMAS OF THE UTERUS

被引：41

作者：

FAN, SX ^{[1
]}

SREEKANTAIAH, C ^{[1
]}

BERGER, CS ^{[1
]}

MEDCHILL, M ^{[1
]}

PEDRON, S ^{[1
]}

SANDBERG, AA ^{[1
]}

机构：

[1] MARICOPA CTY GEN HOSP,DEPT OBSTET & GYNECOL,PHOENIX,AZ

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 47卷 / 02期

关键词：

D O I：

10.1016/0165-4608(90)90028-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal analysis of nine benign leiomyomas of the uterus after short-term culture showed karyotypic abnormalities in four cases. All four exhibited multiple chromosome changes, including three cases characterized by complex chromosome rearrangements involving a number of chromosomes. Among others, these rearrangements included a translocation between chromosomes 12 and 14 in one case, a deletion of chromosome 7q in two cases, and both del(7q) and a complex translocation involving chromosomes 12 and 14 in another case. These results confirm the involvement of chromosomes 7, 12, and 14 in leiomyomas and indicate that benign tumors can also be characterized by complex cytogenetic changes. © 1990.

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页码：179 / 189

页数：11

相关论文

共 36 条

[1] CHROMOSOME LOCALIZATION OF THE HUMAN ONCOGENE INT1 TO 12Q13 BY INSITU HYBRIDIZATION [J].

ARHEDEN, K ;

MANDAHL, N ;

STROMBECK, B ;

ISAKSSON, M ;

MITELMAN, F .

CYTOGENETICS AND CELL GENETICS, 1988, 47 (1-2) :86-87

[2] HUMAN C-FOS ONCOGENE MAPPED WITHIN CHROMOSOMAL REGION 14Q21-]Q31 [J].

BARKER, PE ;

RABIN, M ;

WATSON, M ;

BREG, WR ;

RUDDLE, FH ;

VERMA, IM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (18) :5826-5830

[3] AN INTERSTITIAL DELETION OF CHROMOSOME-7 MAY CHARACTERIZE A SUBGROUP OF UTERINE LEIOMYOMA [J].

BOGHOSIAN, L ;

DALCIN, P ;

SANDBERG, AA .

CANCER GENETICS AND CYTOGENETICS, 1988, 34 (02) :207-208

[4] CLONAL CHROMOSOME REARRANGEMENTS IN A UTERINE MYOMA [J].

GIBAS, Z ;

GRIFFIN, CA ;

EMANUEL, BS .

CANCER GENETICS AND CYTOGENETICS, 1988, 32 (01) :19-24

[5] SIMILAR CHROMOSOMAL EVOLUTION IN A UTERINE STROMOMYOSARCOMA AND IN ONE OF 2 LEIOMYOMAS FROM THE SAME PATIENT [J].

HAVEL, G ;

DAHLENFORS, R ;

WEDELL, B ;

MARK, J .

APMIS, 1989, 97 (02) :143-146

[6] RECIPROCAL TRANSLOCATION T(3-12)(Q27-Q13) IN LIPOMA [J].

HEIM, S ;

MANDAHL, N ;

KRISTOFFERSSON, U ;

MITELMAN, F ;

ROOSER, B ;

RYDHOLM, A ;

WILLEN, H .

CANCER GENETICS AND CYTOGENETICS, 1986, 23 (04) :301-304

[7] STRUCTURAL CHROMOSOME-ABERRATIONS IN A CASE OF ANGIOLEIOMYOMA [J].

HEIM, S ;

MANDAHL, N ;

KRISTOFFERSSON, U ;

MITELMAN, F ;

ROOSER, B ;

RYDHOLM, A ;

WILLEN, H .

CANCER GENETICS AND CYTOGENETICS, 1986, 20 (3-4) :325-330

[8] A SPECIFIC TRANSLOCATION, T(12,14)(Q14-15,Q23-24), CHARACTERIZES A SUBGROUP OF UTERINE LEIOMYOMAS [J].

HEIM, S ;

NILBERT, M ;

VANNI, R ;

FLODERUS, UM ;

MANDAHL, N ;

LIEDGREN, S ;

LECCA, U ;

MITELMAN, F .

CANCER GENETICS AND CYTOGENETICS, 1988, 32 (01) :13-17

[9]

JOHN AH, 1971, J REPROD MED, V6, P56

[10] IDENTIFICATION OF AN AMPLIFIED, HIGHLY EXPRESSED GENE IN A HUMAN GLIOMA [J].

KINZLER, KW ;

BIGNER, SH ;

BIGNER, DD ;

TRENT, JM ;

LAW, ML ;

OBRIEN, SJ ;

WONG, AJ ;

VOGELSTEIN, B .

SCIENCE, 1987, 236 (4797) :70-73

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