OXADIAZOLE CONDENSED RING-SYSTEMS .1. SYNTHESIS OF 1,3,4-OXADIAZOLO[3,2-A]PYRIMIDIN-5-ONES AS POSSIBLE ANTIMICROBIAL AGENTS

被引：3

作者：

BADAWEY, EAM

HASSAN, AMM

SOLIMAN, FSG

机构：

[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

MONATSHEFTE FUR CHEMIE | 1990年 / 121卷 / 8-9期

关键词：

1,3,4-Oxadiazolo[3,2-a]pyrimidin-5-ones; 2-Amino-oxadiazoles; Active malonates;

D O I：

10.1007/BF00809770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses of some substituted 7-hydroxy-5 H-1,3,4-oxadiazolo[3,2-a]pyrimidin-5-ones (3) and their 7-methoxy (4), 7-chloro (5) and 7-azido (6) derivatives are described. 2-Phenyl-N,N′-bis(3-tolyl)propanediamide (8) was obtained, instead of the expected triazolopyrimidinone 7 upon reacting 3b with m-toluidine. Three compounds were screened for in vitro antibacterial and antifungal activities. © 1990 Springer-Verlag.

引用

页码：665 / 669

页数：5

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