INHIBITION OF HIGH-AFFINITY (H-3)L-PROLINE BINDING TO RAT-BRAIN MEMBRANES BY 2-AMINO-7-PHOSPHONOHEPTANOIC ACID

被引：11

作者：

CORDERO, ML

NEGRON, AE

ORTIZ, JG

BLANCO, C

SANTIAGO, G

机构：

[1] Department of Pharmacology, University of Puerto Rico School of Medicine, San Juan, PR

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1991年 / 208卷 / 02期

关键词：

2-AMINO-5-PHOSPHONOHEPTANOIC ACID (AP-7); N-METHYL-D-ASPARTATE (NMDA); PROLINE BINDING; GLUTAMATE;

D O I：

10.1016/0922-4106(91)90070-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

L-Glutamate and 2-amino-5-phosphonoheptanoic acid (AP-7) (10(-9) to 10(-6) M), a competitive NMDA (N-methyl-D-aspartate) antagonist, inhibit almost-equal-to 60% of [H-3]L-proline binding to rat membranes from midbrain. In hippocampal membranes, AP-7 inhibits proline binding by 80%, while in cerebellar membranes AP-7 had little effect. These results are indicative of the possible neuromodulatory role of proline in the central nervous system, possibly through the NMDA receptor(s).

引用

页码：179 / 181

页数：3

共 11 条

[1] L-PROLINE DEPOLARIZES RAT SPINAL MOTONEURONS BY AN EXCITATORY AMINO-ACID ANTAGONIST-SENSITIVE MECHANISM [J].