IMMUNOHISTOCHEMICAL LOCALIZATION OF PITUITARY GONADOTROPINS AND GONADAL-STEROIDS CONFIRMS THE 2-CELL, 2-GONADOTROPIN HYPOTHESIS OF STEROIDOGENESIS IN THE HUMAN OVARY

被引：43

作者：

KOBAYASHI, M ^{[1
]}

NAKANO, R ^{[1
]}

OOSHIMA, A ^{[1
]}

机构：

[1] WAKAYAMA MED COLL,DEPT PATHOL,WAKAYAMA 640,JAPAN

来源：

JOURNAL OF ENDOCRINOLOGY | 1990年 / 126卷 / 03期

关键词：

D O I：

10.1677/joe.0.1260483

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ovaries from 37 women with normal menstrual cycles were analysed for localization of pituitary gonadotrophins and gonadal steroids using an immunohistochemical method. In the follicular phase, FSH and oestradiol-17β localized in the granulosa layer, and LH, progesterone and testosterone localized in the internal thecal layer. In the luteal phase, gonadotrophins and steroids localized in luteal cells. Particularly in the early luteal phase, FSH and oestradiol-17β localized in large luteal cells, and LH, progesterone and testosterone localized in small luteal cells. The results of the present immunohistochemical analysis confirm the two-cell, two-gonadotrophin hypothesis of steroidogenesis in the human ovary.

引用

页码：483 / &

共 26 条

[1] AN IMMUNOHISTOCHEMICAL STUDY OF THE INCIDENCE AND SIGNIFICANCE OF HUMAN GONADOTROPIN AND PROLACTIN BINDING-SITES IN NORMAL AND NEOPLASTIC HUMAN OVARIAN TISSUE [J].