MINIMAL HYPOXIC PULMONARY-HYPERTENSION IN NORMAL TIBETANS AT 3,658-M

被引:197
作者
GROVES, BM
DROMA, T
SUTTON, JR
MCCULLOUGH, RG
MCCULLOUGH, RE
ZHUANG, JG
RAPMUND, G
SUN, SF
JANES, C
MOORE, LG
机构
[1] UNIV COLORADO,DEPT ANTHROPOL,DENVER,CO 80202
[2] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80262
[3] UNIV COLORADO,HLTH SCI CTR,CARDIOVASC PULM RES LAB,DENVER,CO 80262
[4] PEOPLES HOSP,TIBET INST MED SCI,LHASA 850000,PEOPLES R CHINA
[5] UNIV SYDNEY,CUMBERLAND COLL,DEPT BIOL SCI,SYDNEY,NSW 2006,AUSTRALIA
关键词
PULMONARY VASCULAR RESISTANCE; CARDIAC OUTPUT; EXERCISE; TIBET; GENETIC ADAPTATION;
D O I
10.1152/jappl.1993.74.1.312
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Elevated pulmonary arterial pressure in high-altitude residents may be a maladaptive response to chronic hypoxia. If so, well-adapted populations would be expected to have pulmonary arterial pressures that are similar to sea-level values. Five normal male 22-yr-old lifelong residents of greater-than-or-equal-to 3,600 m who were of Tibetan descent were studied in Lhasa (3,658 m) at rest and during near-maximal upright ergometer exercise. We found that resting mean pulmonary arterial pressure [15 +/- 1 (SE) mmHg] and pulmonary vascular resistance (1.8 +/- 0.2 Wood units) were within sea-level norms and were little changed while subjects breathed a hypoxic gas mixture [arterial O2 pressure (Pa(O2)) = 36 +/- 2 Torr]. Near-maximal exercise [87 +/- 13% maximal 02 uptake (VO2(max))] increased cardiac output more than threefold to values of 18.3 +/- 1.2 l/min but did not elevate pulmonary vascular resistance. Breathing 100% O2 during near-maximal exercise did not reduce pulmonary arterial pressure or vascular resistance. We concluded that this small sample of healthy Tibetans with lifelong residence greater-than-or-equal-to 3,658 m had resting pulmonary arterial pressures that were normal by sea-level standards and exhibited minimal hypoxic pulmonary vasoconstriction, both at rest and during exercise. These findings are consistent with remarkable cardiac performance and high-altitude adaptation.
引用
收藏
页码:312 / 318
页数:7
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