GENETIC AND PATHOGENIC BASIS OF AUTOIMMUNE DIABETES IN NOD MICE

被引：113

作者：

SERREZE, DV

LEITER, EH

机构：

[1] The Jackson Laboaratory, Bar Harbor, ME 04609

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 06期

关键词：

D O I：

10.1016/0952-7915(94)90011-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this disease is a result of epistatic interactions between multiple genes, both inside and outside the major histocompatibility complex (MHC), generating T cells reactive against an expanding repertoire of autoantigens.

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页码：900 / 906

页数：7

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