PHARMACOLOGICAL EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR MODIFIED BY POLYETHYLENE-GLYCOL ON ANTICANCER DRUG-INDUCED NEUTROPENIA IN MICE

被引：7

作者：

ISHIKAWA, M ^{[1
]}

OKADA, Y ^{[1
]}

SATAKEISHIKAWA, R ^{[1
]}

KAKITANI, M ^{[1
]}

KAWAGISHI, M ^{[1
]}

MATSUKI, S ^{[1
]}

KUSAKA, M ^{[1
]}

ASANO, K ^{[1
]}

机构：

[1] KIRIN BREWERY CO LTD,PHARMACEUT RES LAB,TAKASAKI,GUMMA 37012,JAPAN

来源：

GENERAL PHARMACOLOGY | 1994年 / 25卷 / 03期

关键词：

GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF); POLYETHYLENE GLYCOL; NEUTROPENIA; CYCLOPHOSPHAMIDE; S-FLUOROURACIL;

D O I：

10.1016/0306-3623(94)90211-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. To clarify the pharmacological effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) conjugated to polyethylene glycol (PEG), its effects on the number of circulating neutrophils in mice made neutropenic by cyclophosphamide (CPA) or 5-fluorouracil (5-FU) were compared with rhG-CSF lacking PEG. 2. In normal mice, PEG-conjugated rhG-CSF (PEG-rhG-CSF, 10 mu g protein/kg) induced an increase in neutrophils which lasted for 72 h after injection whereas the effect of rhG-CSF (10 mu g protein/kg) disappeared by 24 h after injection. 3. In CPA or 5-FU-induced neutropenic mice, PEG-rhG-CSF inhibited neutropenia or accelerated recovery from neutropenia and its potency was higher than that of rhG-CSF. 4. These results indicate that PEG-rhG-CSF has a longer duration of action than rhG-CSF and is more effective in the recovery from neutropenia.

引用

页码：533 / 537

页数：5

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