INTERETHNIC DIFFERENCES IN OMEPRAZOLE METABOLISM IN THE 2 S-MEPHENYTOIN HYDROXYLATION PHENOTYPES STUDIED IN CAUCASIANS AND ORIENTALS

被引:94
作者
ISHIZAKI, T
SOHN, DR
KOBAYASHI, K
CHIBA, K
LEE, KH
SHIN, SG
ANDERSSON, T
REGARDH, CG
LOU, YC
ZHANG, Y
DAHL, ML
BERTILSSON, L
机构
[1] BEIJING MED UNIV,DEPT PHARMACOL,BEIJING,PEOPLES R CHINA
[2] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN CHEM,HUDDINGE,SWEDEN
[3] SEOUL NATL UNIV HOSP,CLIN PHARMACOL UNIT,SEOUL,SOUTH KOREA
[4] NATL MED CTR,CLIN RES INST,DIV CLIN PHARMACOL,TOKYO,JAPAN
[5] GYEONGSANG NATL UNIV,COLL MED,DEPT PHARMACOL,CHINJU,SOUTH KOREA
[6] SEOUL NATL UNIV,COLL MED,DEPT PHARMACOL,SEOUL 151,SOUTH KOREA
[7] ASTRA HASSLE AB,RES LABS,MOLNDAL,SWEDEN
关键词
MEPHENYTOIN; OMEPRAZOLE; PHARMACOGENETICS; INTERETHNIC DIFFERENCE; POLYMORPHIC HYDROXYLATION;
D O I
10.1097/00007691-199404000-00018
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Two independent studies showed that the 5-hydroxylation, but not the sulfoxidation, of omeprazole is more rapid in extensive metabolizers (EMs) than in poor metabolizers (PMs) of S-mephenytoin. In Caucasian, Chinese, and Korean PMs, the mean oral clearances were similar and not significantly different (85, 73, and 59 ml h-1 kg-1, respectively). However, the geometric mean clearance in Caucasian EMs (950 ml h-1 kg-1) was higher than in both Chinese EMs (426 ml h-1 kg-1, p < 0.05) and Korean EMs (446 ml h-1 kg-1, p < 0.01). The incidence of PMs of S-mephenytoin is higher in Chinese (14.6%) and Koreans (12.6%) than in Swedish Caucasians (3.3%). Therefore, the proportion of heterozygous compared to homozygous EMs is higher in Orientals than in Caucasians. This might explain the higher clearance of omeprazole in Caucasian EMs compared to the clearance of omeprazole in Chinese and Korean EMs of S-mephenytoin.
引用
收藏
页码:214 / 215
页数:2
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