EXERCISE ATTENUATES ORAL INTAKE OF AMPHETAMINE IN RATS

被引:53
作者
KANAREK, RB
MARKSKAUFMAN, R
DANCI, KE
PRZYPEK, J
机构
[1] Department of Psychology, Tufts University, Medford
关键词
AMPHETAMINE; EXERCISE; RUNNING WHEELS; FOOD INTAKE; BODY WEIGHT GAIN;
D O I
10.1016/0091-3057(95)00022-O
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of wheel running on oral intake of amphetamine were examined in six male Sprague-Dawley rats given a 0.075-mg/ml amphetamine sulfate solution as their sole source of liquid, six rats given a 0.15-mg/ml amphetamine solution, and four rats given water as their sole source of liquid. All animals were housed in Wahmann running wheels and adjoining cages, and had ad lib access to ground Purina Chow. For the first 7 days of the experiment, the doors to the running wheels were closed; the wheels were then opened for 6 days. This cycle was repeated a second time. Animals drinking the 0.15-mg/ml amphetamine solution consumed significantly less food and gained less weight than animals in the other two groups. Although there was no difference in food intake between rats drinking water and rats drinking the 0.075-mg/ml amphetamine solution, rats in the water group gained significantly more weight than rats in the 0.075-mg/ml amphetamine group. With respect to drug intake, rats consumed significantly less amphetamine when running in the wheels than when access to the wheels was prohibited. Access to running wheels did not alter water intake. These latter results suggest that drug intake can be reduced by the provision of an alternate behavior.
引用
收藏
页码:725 / 729
页数:5
相关论文
共 37 条
[1]  
BARRETT JE, 1985, NEUROLOGY NEUROBIOLO, V13, P7
[2]  
BLASS EM, 1989, ANN NY ACAD SCI, V575, P292
[3]  
BRADY JV, 1985, ADV BEHAV PHARMACOL, V13, P361
[5]  
CARROLL ME, 1983, J PHARMACOL EXP THER, V227, P28
[6]  
CARROLL ME, 1979, PHARM BIOCH BEHAV, V20, P155
[7]  
CARROLL ME, 1979, PHARM BIOCH BEHAV, V17, P563
[8]  
Catania A. C., 1966, OPERANT BEHAV AREAS, P213
[9]   OPIOID MODULATION OF FEEDING-BEHAVIOR FOLLOWING FORCED SWIMMING EXERCISE IN MALE-RATS [J].
DAVIS, JM ;
LAMB, DR ;
LOWY, MT ;
YIM, GKW ;
MALVEN, PV .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1985, 23 (05) :701-707
[10]   OPIOID MODULATION OF FEEDING-BEHAVIOR FOLLOWING REPEATED EXPOSURE TO FORCED SWIMMING EXERCISE IN MALE-RATS [J].
DAVIS, JM ;
LAMB, DR ;
YIM, GKW ;
MALVEN, PV .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1985, 23 (05) :709-714