SUPPRESSION OF GRAFT-VERSUS-HOST DISEASE AND ANTIBODY FORMATION BY PHYTOHEMAGGLUTININ - EXAMPLES OF ANTIGEN COMPETITION

被引：18

作者：

HUNTER, RL

MILLMAN, RB

LERNER, EM

机构：

[1] Department of Pathology, University of Chicago, Chicago, IL

[2] Department of Medicine, New York Hospital Center, New York, NY

[3] National Institute of Allergy and In-fectious Diseases, National Institutes of Health, Bethesda, MD

来源：

TRANSPLANTATION | 1969年 / 8卷 / 04期

关键词：

D O I：

10.1097/00007890-196910000-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phytohemagglutinin (PHA) has been used to suppress both graftversus- host disease and antibody formation in mice. However, PHA heated at 100 C for 30 min to destroy its in vitro mitogenicity and certain antigens produced quantitatively similar suppression. Consequently, the immunosuppressive effects of PHA demonstrated in our experiments were unrelated to its in vitro mitogenicity and are probably results of antigen competition. © 1969 by the Williams and Wilkins Co.

引用

页码：413 / &

共 27 条

[1] COMPETITION OF ANTIGENS [J].