CARDIOVASCULAR AND RESPIRATORY EFFECTS OF SOME ANESTHETICS IN THE DECEREBRATE RAT

被引：72

作者：

SAPRU, HN ^{[1
]}

KRIEGER, AJ ^{[1
]}

机构：

[1] COLL MED & DENT NEW JERSEY, NEW JERSEY MED SCH, NEUROL SURG SECT, NEWARK, NJ 07103 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 53卷 / 02期

关键词：

Blood pressure; Carotid occlusion; Chloralose; Heart rate; Ketamine; Orthostatic reflex; Pentobarbital; Respiration; Sodium cyanide; Urethane;

D O I：

10.1016/0014-2999(79)90160-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cardiovascular and respiratory effects of pentobarbital, ketamine, chloralose and urethane were studied in decerebrate rats. All the reduced blood pressure and heart rate. Pentobarbital, chloralose and ketomine, but not urethane, reduced respiratory rate. None of these agents had a significant effect on tidal volume. All these anesthetics significantly attenuated the carotid occlusion, tilt and sodium cyanide chemoreceptor. response. These results suggest that the decebrate rat may be a more suitable preparation, compared to the anesthetized one, for studying cardiovascular and respiratory responses in this species. © 1979.

引用

页码：151 / 158

页数：8

共 35 条

[1] ALTERATION OF CAROTID OCCLUSION RESPONSE BY ANESTHESIA [J].

ARMSTRONG, G ;

PORTER, H ;

LANGSTON, JB .

AMERICAN JOURNAL OF PHYSIOLOGY, 1961, 201 (05) :897-&

[2] CARDIOVASCULAR-RESPONSES TO NORADRENALINE IN RAT BEFORE AND AFTER ADMINISTRATION OF VARIOUS ANESTHETICS [J].

BREZENOFF, HE .

BRITISH JOURNAL OF PHARMACOLOGY, 1973, 49 (04) :565-572

[3] REDUCED CARDIOVASCULAR RESPONSIVENESS TO HYPOTHALAMIC STIMULATION DURING URETHANE AND AMOBARBITAL ANESTHESIA [J].

BUNAG, RD ;

EFERAKEYA, JE .

PHARMACOLOGY, 1973, 10 (03) :143-151

[4] INTEGRATION OF SYMPATHETIC CARDIOVASCULAR MECHANISMS IN MEDULLA OBLONGATA OF CAT [J].

CHAI, CY ;

WANG, SC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 215 (06) :1310-&

[5] CARDIOVASCULAR EFFECTS OF 2-(O-CHLOROPHENYL)-2-METHYLAMINOCYCLOHEXANONE (CI-581) IN RATS [J].

CHANG, P ;

CHAN, KE ;

GANENDRAN, A .

BRITISH JOURNAL OF ANAESTHESIA, 1969, 41 (05) :391-+

[6]

CIER JF, 1951, CR SOC BIOL, V145, P1541

[7] CARDIOVASCULAR EFFECTS OF KETAMINE IN PITHED RAT, RABBIT AND CAT [J].

CLANACHAN, AS ;

MCGRATH, JC ;

MACKENZIE, JE .

BRITISH JOURNAL OF ANAESTHESIA, 1976, 48 (10) :935-939

[8]

CROXTON RE, 1959, ELEMENTARY STATISTIC, P235

[9] KETAMINE - RATIONAL USE OF KETAMINE AS AN ANAESTHETIC [J].

DILLON, JB .

PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1971, 64 (11) :1153-&

[10]

DOMINO EF, 1965, CLIN PHARMACOL THER, V6, P279

← 1 2 3 4 →