PHARMACOKINETICS OF FENTANYL AS A POSSIBLE EXPLANATION FOR RECURRENCE OF RESPIRATORY DEPRESSION

被引：123

作者：

STOECKEL, H ^{[1
]}

HENGSTMANN, JH ^{[1
]}

SCHUTTLER, J ^{[1
]}

机构：

[1] UNIV BONN,DEPT INTERNAL MED,D-5300 BONN 1,FED REP GER

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1979年 / 51卷 / 08期

关键词：

D O I：

10.1093/bja/51.8.741

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The pharmacokinetics of fentanyl are complicated by an additional increase in plasma concentration during the elimination phase of the drug. We have confirmed that fentanyl is excreted in the gastric juice and reabsorbed from the alkaline medium of the small intestine. In addition, the stomach wall in rats has an important storage capacity for fentanyl. A maximum of about 20% of the dose was found in the stomach wall after i.v. injection. In man the resected part of the stomach contained 16% of the dose, 10 min after injection. These observations could be important in explaining the occurrence of respiratory depression in the period after operation. © 1979 Macmillan Journals Ltd.

引用

页码：741 / 745

页数：5

共 9 条

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