IMMUNOPROTECTION OF PANCREATIC-ISLET GRAFTS WITHIN ARTIFICIAL MICROCAPSULES

被引：29

作者：

BRUNETTI, P ^{[1
]}

BASTA, G ^{[1
]}

FALOERNI, A ^{[1
]}

CALCINARO, F ^{[1
]}

PIETROPAOLO, M ^{[1
]}

CALAFIORE, R ^{[1
]}

机构：

[1] CONSORZIO INTER UNIV TRAPIANTO ORGANO,PERUGIA,ITALY

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 1991年 / 14卷 / 12期

关键词：

DIABETES; INSULIN; TRANSPLANT; IMMUNE REJECTION; ISLETS; MICROCAPSULES;

D O I：

10.1177/039139889101401208

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To circumvent pancreatic islet graft-directed immune destruction we enveloped porcine islets within highly biocompatible and selectively permeable algin/polyaminoacid microcapsules. These special microspheres were deposited between the inner (permeable) and the outer (impermeable) layers of an artificial, coaxial vascular prosthesis, directly anastomized to blood vessels. Five dogs with spontaneous, insulin-dependent diabetes received microencapsulated porcine islets in arterio-vein iliac prosthesis by-passes. One showed complete and the remainder partial, sustained reversal of hyperglycemia. Microencapsulation may be a potential solution to immunological problems related to islet transplantation.

引用

页码：789 / 791

页数：3

共 6 条

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