SYNTHESIS OF POLY(METHYL METHACRYLATE) MICROSPHERES BEARING PHOSPHATIDYLCHOLINE ANALOGOUS AND AZOBENZENE MOIETIES

被引：20

作者：

SUGIYAMA, K

SHIRAISHI, K

OHGA, K

SHIRAHAMA, H

TAMAI, H

KIKUKAWA, K

YASUDA, H

机构：

[1] KINKI UNIV KYUSHU,IIZUKA,FUKUOKA 820,JAPAN

[2] HIROSHIMA UNIV,FAC ENGN,DEPT APPL CHEM,HIROSHIMA 724,JAPAN

来源：

POLYMER JOURNAL | 1993年 / 25卷 / 05期

关键词：

EMULSION POLYMERIZATION; MICROSPHERE; PHOSPHATIDYLCHOLINE ANALOGOUS MONOMER; POLY(METHYL METHACRYLATE); AZOBENZENE MOIETIES; ALBUMIN ADSORPTION; XPS;

D O I：

10.1295/polymj.25.521

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Microsphere, Poly(MAHP-co-MMA), was prepared by the emulsifier free emulsion copolymerization of 2-[2-(methacryloyloxy)ethyldimethylammonio]ethyl-6-[4-(4-methoxyphenylazo)phenoxy]hexyloxyphosphate (MAHP) and methyl methacrylate (MMA). The diameter of poly (MAHP-co-MMA) estimated from TEM varied from 234 to 402 nm. depending on the mol-% of MAHP to MMA in feed from f = 0 to f = 0.5. From XPS measurements of poly (MAHP-co-MMA) the polar head groups of MAHP were found to be located on the surface of particles. The adsorption of bovine serum albumin (BSA) onto poly(methyl methacrylate) [poly(MMA)] and poly(MAHP-co-MMA) microspheres were examined at pH 5.6. The introduction of phosphatidylcholine analog into poly(MMA) results in a drastic decrease in BSA adsorption. A controlled decrease in BSA adsorption was also observed in poly(MAHP-co-MMA) with cis-azobenzene moieties caused by UV irradiation.

引用

页码：521 / 527

页数：7

共 31 条

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