CONFORMATIONAL AND FUNCTIONAL-PROPERTIES OF PEPTIDES COVERING THE INTERSUBUNIT REGION OF INFLUENZA-VIRUS HEMAGGLUTININ

被引：19

作者：

HOLLOSI, M

ISMAIL, AA

MANTSCH, HH

PENKE, B

VARADI, IG

TOTH, GK

LACZKO, I

KURUCZ, I

NAGY, Z

FASMAN, GD

RAJNAVOLGYI, E

机构：

[1] NATL RES COUNCIL CANADA, STEACIE INST MOLEC SCI, OTTAWA K1A 0R6, ONTARIO, CANADA

[2] EOTVOS LORAND UNIV, DEPT ORGAN CHEM, H-1364 BUDAPEST 5, HUNGARY

[3] A SZENTGYORGYI MED UNIV, DEPT MED CHEM, SZEGED, HUNGARY

[4] BIOL RES CTR, INST BIOPHYS, H-6701 SZEGED, HUNGARY

[5] INST DRUG RES, H-1325 BUDAPEST, HUNGARY

[6] EOTVOS LORAND UNIV, DEPT IMMUNOL, GOD, HUNGARY

[7] BRANDEIS UNIV, DEPT BIOCHEM, WALTHAM, MA 02254 USA

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1992年 / 206卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1992.tb16942.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functionally active part of influenza virus hemagglutinin was investigated through the synthesis of a series of peptides representing different parts of the intersubunit region. Secondary structure prediction, circular dichroism and Fourier transform infrared spectroscopic studies were undertaken to investigate the secondary structure of these peptides. The peptide fragments were found to adopt multiple conformations, depending on their concentration in solution, the presence of the non-ionic detergent octyl-beta-D-glucoside and the polarity of the solvent. The results of biological studies with these peptide fragments are discussed in relation to their conformation, as inferred from the spectroscopic analysis.

引用

页码：421 / 425

页数：5

共 27 条

[1] PROTEIN ANTIGENIC STRUCTURES RECOGNIZED BY T-CELLS - POTENTIAL APPLICATIONS TO VACCINE DESIGN [J].