SEQUESTRATION PATTERN OF PARASITIZED ERYTHROCYTES IN CEREBRUM, MID-BRAIN, AND CEREBELLUM OF PLASMODIUM-COATNEYI-INFECTED RHESUS-MONKEYS (MACACA-MULATTA)

被引：33

作者：

SEIN, KK

BROWN, AE

MAENO, Y

SMITH, CD

CORCORAN, KD

HANSUKJARIYA, P

WEBSTER, HK

AIKAWA, M

机构：

[1] CASE WESTERN RESERVE UNIV, INST PATHOL, 2085 ADELBERT RD, CLEVELAND, OH 44106 USA

[2] WALTER REED ARMY INST RES, DIV RETROVIROL, WASHINGTON, DC 20307 USA

[3] ARMED FORCES RES INST MED SCI, USA MED COMPONENT, DEPT VET MED, BANGKOK, THAILAND

[4] WALTER REED ARMY INST RES, DEPT PARASITOL, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1993年 / 49卷 / 04期

关键词：

D O I：

10.4269/ajtmh.1993.49.513

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Six rhesus monkeys (Macaca mulatta) infected with Plasmodium coatneyi were studied for parasitized red blood cell (PRBC) sequestration in microvessels of the brain. The degree of PRBC sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequestration occurring preferentially in the cerebellum. This pattern resembles that of PRBC sequestration in cerebral and cerebellar microvessels in human falciparum malaria. The morphologic appearance of sequestered cells under light and electron microscopy as well as the PRBC sequestration pattern bolsters the contention that the rhesus monkey infected with P. coatneyi is an appropriate primate model for the experimental study of human cerebral malaria.

引用

页码：513 / 519

页数：7

共 31 条

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