PALLADIUM-CATALYZED TRANSFORMATION OF A CHIRAL VINYLAZIRIDINE TO A BETA-LACTAM - AN ENANTIOSELECTIVE ROUTE TO THE CARBAPENEM (+)-PS-5

被引:67
作者
TANNER, D [1 ]
SOMFAI, P [1 ]
机构
[1] LUND INST TECHNOL, S-22100 LUND, SWEDEN
关键词
D O I
10.1016/S0960-894X(01)80967-7
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The regio- and stereoselective carbonylation of optically pure trans vinylaziridine 5 to trans 3-vinylazetidinone 6 is catalyzed by Pd(0). Compound 6 is then transformed to a known key intermediate for the total synthesis of the carbapenem antibiotic (+)-PS-5.
引用
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页码:2415 / 2418
页数:4
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