SEIZURE THRESHOLD ADRENALECTOMY AND SODIUM-POTASSIUM STIMULATED ATPASE IN RAT BRAIN

被引：11

作者：

BALLAGHE.BB

GLASER, GH

机构：

[1] Division of Neurology, Yale University School of Medicine, New Haven, Connecticut

来源：

JOURNAL OF NEUROCHEMISTRY | 1968年 / 15卷 / 06期

关键词：

D O I：

10.1111/j.1471-4159.1968.tb08950.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adrenalectomy in the rat was shown to lower seizure threshold measured with the volatile convulsant hexafluorodiethyl ether. Although the expected hyponatraemia and hyperkalaemia were demonstrated in the adrenalectomized rats, there was no associated alteration in Na‐K stimulated Mg‐ATPase activity either in the whole rat brain or in a microsomal fraction. These results in brain tissue are contrasted with the marked decrease in this enzyme that occurs in kidney tissue of the rat following adrenalectomy. It was suggested that the activity of the enzyme system responsible for active cation transport responds directly in proportion to the work of active transport required by the individual tissue. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：525 / &

共 13 条

[1]

CHIGNELL CF, 1966, J BIOL CHEM, V241, P5083

[2]

CHIGNELL COLIN F., 1965, LIFE SCI, V4, P559

[3] DETERMINATION OF TRUE CHLORIDE CONTENT OF BIOLOGICAL FLUIDS AND TISSUES .2. ANALYSIS BY SIMPLE, NONISOTOPIC METHODS [J].