EFFECTS OF CHRONIC LEAD ADMINISTRATION ON ACQUISITION AND PERFORMANCE OF SERIAL POSITION SEQUENCES BY PIGEONS

被引:20
作者
DIETZ, DD
MCMILLAN, DE
MUSHAK, P
机构
[1] UNIV N CAROLINA,SCH MED,DEPT PHARMACOL,CHAPEL HILL,NC 27514
[2] UNIV N CAROLINA,SCH MED,DEPT PATHOL,CHAPEL HILL,NC 27514
关键词
D O I
10.1016/0041-008X(79)90333-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Male White Carneaux pigeons were trained to peck three illuminated response keys in a predetermined four-step position sequence. For one group of birds the correct sequence was changed each day (repeated acquisition group) and for the other group of birds the sequence remained the same each day (performance group). Errors committed during periods of chronic intragastric sodium acetate (initial and recovery control) were compared to those errors recorded during chronic intragastric 6.25 mg/kg lead acetate intubation. Errors by birds in the performance group increased soon after lead intubations were begun while birds in the repeated acquisition group failed to demonstrate visible increases in errors, although a split middle trend analysis detected a statistically significant error increase during lead intervention in both groups. Peak blood concentrations for the performance group ranged between 588 and 1099 μg/dl and between 876 and 2320 μg/dl for the repeated acquisition group. Decreases in blood lead concentrations were seen approximately 5 weeks after termination of lead exposure. Only one performance bird showed a satisfactory recovery during this nonlead period. These data suggest that the more stable error rates maintained under the performance schedule are more sensitive to the effects of lead than the less stable error rates maintained under the acquisition schedule. © 1979.
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页码:377 / 384
页数:8
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