CONTROLLED-STUDY OF PNEUMOCOCCAL POLYSACCHARIDE VACCINE IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：85

作者：

KLIPPEL, JH ^{[1
]}

KARSH, J ^{[1
]}

STAHL, NI ^{[1
]}

DECKER, JL ^{[1
]}

STEINBERG, AD ^{[1
]}

SCHIFFMAN, G ^{[1
]}

机构：

[1] SUNY DOWNSTATE MED CTR,DEPT MICROBIOL & IMMUNOL,BROOKLYN,NY 11203

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 12期

关键词：

D O I：

10.1002/art.1780221201

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The immunogenicity and potential for disease modification of pneumococcal polysaccharide vaccine in systemic lupus erythematosus were evaluated in a controlled, double‐blind study. Forty patients were randomly chosen to receive an intramuscular injection of either vaccine or placebo. Changes in mean antibody concentrations (nanograms antibody nitrogen per milliliter serum) to 12 type‐specific pneumococcal capsular antigens from prevaccination to one month after vaccination were 177 to 1045 in the vaccine (P < 0.001) and 164 to 153 in the placebo‐treated patients. In the month after vaccination, neither vaccine nor placebo‐treated patients had a significant change in lupus disease activity as assessed by a composite clinical, laboratory, and serologic index. We conclude that patients with systemic lupus erythematosus can be successfully immunized with pneumococcal vaccine without detectable alterations of the underlying disease. Copyright © 1979 American College of Rheumatology

引用

页码：1321 / 1325

页数：5

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