KINETIC AND CROSS-LINKING STUDIES INDICATE DIFFERENT RECEPTORS FOR ENDOTHELINS AND SARAFOTOXINS IN THE ILEUM AND CEREBELLUM

被引：24

作者：

GALRON, R

BDOLAH, A

KOCHVA, E

WOLLBERG, Z

KLOOG, Y

SOKOLOVSKY, M

机构：

[1] TEL AVIV UNIV,DEPT BIOCHEM,NEUROBIOCHEM LAB,IL-69978 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,DR GEORGE S WISE CTR LIFE SCI,DEPT ZOOL,TEL AVIV,ISRAEL

来源：

FEBS LETTERS | 1991年 / 283卷 / 01期

关键词：

RECEPTOR SUBTYPE; ENDOTHELIN-1; ENDOTHELIN-3; RATE OF DISSOCIATION; AFFINITY LABELING; BRAIN; PERIPHERAL; SARAFOTOXIN;

D O I：

10.1016/0014-5793(91)80542-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different tissues support these conclusions.

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页码：11 / 14

页数：4

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