NGF RESTORES DECREASE IN CATALASE AND INCREASES GLUTATHIONE-PEROXIDASE ACTIVITY IN THE BRAIN OF AGED RATS

被引：26

作者：

NISTICO, G ^{[1
]}

CIRIOLO, MR ^{[1
]}

FISKIN, K ^{[1
]}

IANNONE, M ^{[1
]}

DEMARTINO, A ^{[1
]}

ROTILIO, G ^{[1
]}

机构：

[1] UNIV ROME TOR VERGATA, DEPT BIOL, CHAIR BIOCHEM, ROME, ITALY

来源：

NEUROSCIENCE LETTERS | 1991年 / 130卷 / 01期

关键词：

NERVE GROWTH FACTOR; CATALASE; GLUTATHIONE PEROXIDASE; AGING; BRAIN AREA;

D O I：

10.1016/0304-3940(91)90241-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of subchronic administration of nerve growth factor (NGF) into the lateral ventricle on catalase and selenium-dependent glutathione-peroxidase (GSH-Px) activity in several areas of the brain in 3-, 12- and 24-month-old rats were studied. NGF given daily (1-mu-g for 28 consecutive days) produced in all brain areas studied a significant increase in catalase activity in 12- and 24-month-old rats. The most important finding was a complete restoration in 12- and 24-month-old rats of catalase activity to levels similar to those occurring in young (3-month-old) rats. In addition, NGF produced in comparison to 3-month-old rats and to same age vehicle-treated rats a significant increase in selenium-dependent GSH-Px in all the brain areas studied in 12- and 24-month-old animals, whereas selenium-independent GSH-Px was unaffected. In conclusion, the present results show that long-term administration of NGF into the lateral ventricle significantly increases in old animals the activity of key enzymes involved in the metabolic degradation of hydrogen peroxide.

引用

页码：117 / 119

页数：3

共 24 条

[1] X-RAY-DIFFRACTION EVIDENCE FOR MYELIN DISORDER IN BRAIN FROM HUMANS WITH ALZHEIMERS-DISEASE [J].

CHIA, LS ;

THOMPSON, JE ;

MOSCARELLO, MA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 775 (03) :308-312

[2] INTERACTION BETWEEN NERVE GROWTH-FACTOR AND GM1 MONOSIALOGANGLIOSIDE IN PREVENTING CORTICAL CHOLINE-ACETYLTRANSFERASE AND HIGH-AFFINITY CHOLINE UPTAKE DECREASE AFTER LESION OF THE NUCLEUS BASALIS [J].

DIPATRE, PL ;

CASAMENTI, F ;

CENNI, A ;

PEPEU, G .

BRAIN RESEARCH, 1989, 480 (1-2) :219-224

[3] EFFECTS OF NERVE GROWTH-FACTOR ON CHOLINERGIC BRAIN NEURONS [J].

DREYFUS, CF .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (04) :145-149

[4] AMELIORATION OF CHOLINERGIC NEURON ATROPHY AND SPATIAL MEMORY IMPAIRMENT IN AGED RATS BY NERVE GROWTH-FACTOR [J].

FISCHER, W ;

WICTORIN, K ;

BJORKLUND, A ;

WILLIAMS, LR ;

VARON, S ;

GAGE, FH .

NATURE, 1987, 329 (6134) :65-68

[5]

FLOYD RA, 1984, FREE RADICALS MOL BI, P143

[6]

FRIDOVICH I, 1974, ADV ENZYMOL RAMB, V41, P35

[7] NERVE GROWTH-FACTOR AFFECTS UNINJURED, ADULT-RAT SEPTOHIPPOCAMPAL CHOLINERGIC NEURONS [J].

FUSCO, M ;

ODERFELDNOWAK, B ;

VANTINI, G ;

SCHIAVO, N ;

GRADKOWSKA, M ;

ZAREMBA, M ;

LEON, A .

NEUROSCIENCE, 1989, 33 (01) :47-52

[8] FREE-RADICAL THEORY OF AGING - CONSEQUENCES OF MITOCHONDRIAL AGING [J].

HARMAN, D .

AGE, 1983, 6 (03) :86-94

[9] THE AGING PROCESS [J].

HARMAN, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :7124-7128

[10] ROLE OF NERVE GROWTH-FACTOR IN OXIDANT-ANTIOXIDANT BALANCE AND NEURONAL INJURY .1. STIMULATION OF HYDROGEN-PEROXIDE RESISTANCE [J].

JACKSON, GR ;

APFFEL, L ;

WERRBACHPEREZ, K ;

PEREZPOLO, JR .

JOURNAL OF NEUROSCIENCE RESEARCH, 1990, 25 (03) :360-368

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