LYTIC ACTIVITY FROM SCHISTOSOMES - INTERACTIONS WITH BLOOD-CELLS

被引：3

作者：

KASSCHAU, MR

GENTRY, DL

BYAMSMITH, MP

机构：

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1991年 / 98卷 / 2-3期

关键词：

D O I：

10.1016/0305-0491(91)90166-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The schistosome lytic agent hemolyzed animal red blood cells (RBCs) containing high concentrations of membrane phosphatidyl choline (dog, mouse, and rat) more efficiently than RBCs having no phosphatidyl choline (goat and sheep). 2. Human mononuclear cells lost viability in the presence of the schistosome lytic agent. 3. Preincubating the lytic agent with phosphatidyl choline or bovine serum albumin reduced its lytic activity. 4. Extracellular albumin protected the RBCs from schistosome induced hemolysis. 5. Pretreatment of the RBCs with various proteases enhanced lysis by 10-30%.

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页码：195 / 200

页数：6

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