SYNTHESES OF NOVEL 25-HYDROXY-VITAMIN-D3 HAPTENS HAVING CHEMICAL BRIDGES AT THE C-11 ALPHA-POSITION

被引:14
作者
KOBAYASHI, N [1 ]
HISADA, A [1 ]
SHIMADA, K [1 ]
机构
[1] KANAZAWA UNIV,FAC PHARMACEUT SCI,13-1 TAKARA MACHI,KANAZAWA,ISHIKAWA 920,JAPAN
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 01期
关键词
D O I
10.1039/p19930000031
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The serum or plasma levels of 25-hydroxyvitamin D3 la is useful for the evaluation of vitamin D status in various clinical or nutritional disorders. To obtain antibodies to compound 1 a which are highly specific and useful for development of immunoassays, two novel haptenic derivatives, 11-alpha-(3-carboxypropionyloxy)-25-hydroxyvitamin D3 2a and 11 alpha-(4-carboxybutyryloxy)-25-hydroxyvitamin D3 2b were synthesized each in 21 steps from 11 alpha-hydroxydehydroepiandrosterone 3.
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页码:31 / 37
页数:7
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