A NEW CLASS OF CHIRAL MODIFIERS FOR THE ENANTIOSELECTIVE HYDROGENATION OF ALPHA-KETOESTERS WITH PT/AL2O3

被引：71

作者：

SIMONS, KE

WANG, GZ

HEINZ, T

GIGER, T

MALLAT, T

PFALTZ, A

BAIKER, A

机构：

[1] UNIV BASEL,INST ORGAN CHEM,CH-4056 BASEL,SWITZERLAND

[2] ETH ZENTRUM,DEPT CHEM ENGN & IND CHEM,CH-8092 ZURICH,SWITZERLAND

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 02期

关键词：

D O I：

10.1016/0957-4166(95)00034-M

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of enantiomerically pure chiral amino alcohols have been synthesized and applied as modifiers in the enantioselective hydrogenation of ethyl pyruvate over supported Pt catalysts. Their use enabled an enantiomeric excess of up to 75 %. A molecular modelling study of the modifiers and reactant on a Pt (111) surface provides a possible explanation for the observed enantiodifferentiation.

引用

页码：505 / 518

页数：14

共 26 条

[1] ENANTIOSELECTIVE HETEROGENEOUS CATALYSIS .1. A WORKING MODEL FOR THE CATALYST-MODIFIER-SUBSTRATE INTERACTIONS IN CHIRAL PYRUVATE HYDROGENATIONS [J].