ARTEETHER ADMINISTRATION IN HUMANS - PRELIMINARY STUDIES OF PHARMACOKINETICS, SAFETY AND TOLERANCE

被引：31

作者：

KAGER, PA ^{[1
]}

SCHULTZ, MJ ^{[1
]}

ZIJLSTRA, EE ^{[1
]}

VANDENBERG, B ^{[1
]}

VANBOXTEL, CJ ^{[1
]}

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN PHARMACOL,1105 AZ AMSTERDAM,NETHERLANDS

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷

关键词：

D O I：

10.1016/0035-9203(94)90475-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The recently developed artemisinin derivative arteether was administered by intramuscular injection to healthy male subjects in a single dose (n=23) and a multiple dose study (n=27). The drug was well tolerated. Clinical, neurological, electrocardiographic and biochemical monitoring did not reveal significant toxicity. Apart from some increase in eosinophil numbers, no haematological abnormality was seen. Preliminary pharmacokinetic data showed a long elimination half life of 25-72 h and marked accumulation in the multiple dose study.

引用

页码：53 / 54

页数：2

共 5 条

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