EFFECTS OF DOPAMINE D1 AND D2 RECEPTOR AGONISTS AND ANTAGONISTS ON BASAL AND ETHANOL-MODULATED BETA-ENDORPHIN SECRETION FROM HYPOTHALAMIC NEURONS IN PRIMARY CULTURES

被引:2
作者
BOYADJIEVA, NI [1 ]
SARKAR, DK [1 ]
机构
[1] WASHINGTON STATE UNIV,DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL,PULLMAN,WA 99164
关键词
DOPAMINE; ETHANOL; BETA-ENDORPHIN; PRIMARY CULTURES; HYPOTHALAMIC NEURONS; D1 AND D2 RECEPTOR AGONISTS; D1 AND D2 RECEPTOR ANTAGONISTS;
D O I
10.1111/j.1365-2826.1995.tb00720.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the present study, we determined the effects of dopamine receptor agonists and antagonists on basal and ethanol-modulated beta-endorphin (beta-EP) secretion from hypothalamic neurons in primary cultures. Treatment with various concentrations of dopamine DI agonist SKF 38393 and D1 antagonist SCH 23390 did not affect basal IR-beta-EP release. However, dopamine D2 receptor agonist LY 141865 reduced basal immunoreactive (IR)-beta-EP release in a concentration dependent manner. D2 receptor antagonist, sulpiride, on the other hand, stimulated basal IR-beta-EP release and blocked LY 141865-induced inhibition of IR-beta-EP release in a concentration dependent manner. When the actions of these DA receptor agents on ethanol-modulated IR-beta-EP release were studied, both D1 and D2 receptor agents failed to affect ethanol-modulated IR-beta-EP release. These data suggest that the endogenous secretion of beta-EP from hypothalamic neurons is under the influence of an inhibitory dopaminergic system involving the D2 receptor. Furthermore, ethanol's effects on beta-EP secretion are not mediated by dopamine.
引用
收藏
页码:819 / 825
页数:7
相关论文
共 57 条
[1]   INTRAVENTRICULAR BETA-ENDORPHIN ACCUMULATES IN DARPP-32 IMMUNOREACTIVE TANYCYTES [J].
BJELKE, B ;
FUXE, K .
NEUROREPORT, 1993, 5 (03) :265-268
[2]   EFFECTS OF CHRONIC ALCOHOL ON IMMUNOREACTIVE BETA-ENDORPHIN SECRETION FROM HYPOTHALAMIC NEURONS IN PRIMARY CULTURES - EVIDENCE FOR ALCOHOL TOLERANCE, WITHDRAWAL, AND SENSITIZATION RESPONSES [J].
BOYADJIEVA, NI ;
SARKAR, DK .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1994, 18 (06) :1497-1501
[3]   COMPARATIVE-STUDY OF THE NEURONAL POPULATIONS CONTAINING BETA-ENDORPHIN, CORTICOTROPIN AND DOPAMINE IN THE ARCUATE NUCLEUS OF THE RAT HYPOTHALAMUS [J].
BUGNON, C ;
BLOCH, B ;
LENYS, D ;
GOUGET, A ;
FELLMANN, D .
NEUROSCIENCE LETTERS, 1979, 14 (01) :43-48
[4]   EFFECT OF ACUTE ETHANOL TREATMENT ON TRANSMITTER SYNTHESIS AND METABOLISM IN CENTRAL DOPAMINERGIC-NEURONS [J].
BUSTOS, G ;
ROTH, RH .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1976, 28 (07) :580-582
[5]  
CHARNESS ME, 1992, DIAGNOSIS TREATMENT, P155
[6]   ENDOGENOUS OPIOID-PEPTIDES - A GUIDE TO STRUCTURES AND TERMINOLOGY [J].
COX, BM .
LIFE SCIENCES, 1982, 31 (16-1) :1645-1658
[7]  
DAR M S, 1984, Alcohol, V1, P453, DOI 10.1016/0741-8329(84)90021-1
[8]   ETHANOL DECREASES CORTICOTROPIN-RELEASING FACTOR BINDING, ADENYLATE-CYCLASE ACTIVITY, PROOPIOMELANOCORTIN BIOSYNTHESIS, AND BETA-ENDORPHIN RELEASE IN CULTURED PITUITARY-CELLS [J].
DAVE, JR ;
ESKAY, RL .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 492 :327-330
[9]  
DE A, 1994, J BIOL CHEM, V269, P26696
[10]   LACK OF A HIGH-AFFINITY TRANSPORT-SYSTEM FOR DOPAMINE IN THE MEDIAN-EMINENCE AND POSTERIOR PITUITARY [J].
DEMAREST, KT ;
MOORE, KE .
BRAIN RESEARCH, 1979, 171 (03) :545-551