STUDIES ON ANTIPROTOZOANS . SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME STYRYLIMIDAZOLE DERIVATIVES

被引：11

作者：

GIRALDI, PN

MARIOTTI, V

DECARNER.I

机构：

[1] Chemistry Research Department and Microbiology Department, Istituto Carlo Erba per Ricerche Terapeutiche, Milan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 01期

关键词：

D O I：

10.1021/jm00307a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-aminoalkyl- and 1-aminoalkyl-2-methyl-5(4)-nitro-4(5)-styrylimidazoles were synthesized and examined for biological activity. These compounds were tested on Trichomonas vaginalis, Entamoeba histolytica, and Candida albicans. Their in vitro activity against T. vaginalis was found particularly interesting. For the 1-aminoalkyl-5(4)-nitro-4(5)-styrylimidazoles, we have separated isomers and determined their activities. Different methods used to assign positions to the nitro group in the heterocyclic ring are described. © 1968, American Chemical Society. All rights reserved.

引用

页码：66 / +

页数：1

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