MK-801 POTENTLY INHIBITS ALCOHOL-WITHDRAWAL SEIZURES IN RATS

被引：155

作者：

MORRISETT, RA

REZVANI, AH

OVERSTREET, D

JANOWSKY, DS

WILSON, WA

SWARTZWELDER, HS

机构：

[1] DUKE UNIV,MED CTR,DEPT MED NEUROL,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DEPT PHARMACOL,DURHAM,NC 27710

[3] DUKE UNIV,MED CTR,DEPT PSYCHOL,DURHAM,NC 27710

[4] UNIV N CAROLINA,SCH MED,CTR ALCOHOL STUDIES,CHAPEL HILL,NC 27514

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 01期

关键词：

Alcohol withdrawal; Ethanol; Excitatory amino acid; MK-801; NMDA (N-methyl-D-aspartate); Seizure;

D O I：

10.1016/0014-2999(90)90138-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes. © 1990.

引用

页码：103 / 105

页数：3

共 7 条

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