ANHYDROTETRACYCLINE OXYGENASE ACTIVITY AND BIOSYNTHESIS OF TETRACYCLINES IN STREPTOMYCES AUREOFACIENS

被引：42

作者：

BEHAL, V

HOSTALEK, Z

VANEK, Z

机构：

[1] Institute of Microbiology, Czechoslovak Academy of Sciences, Prague 4

来源：

BIOTECHNOLOGY LETTERS | 1979年 / 1卷 / 04期

关键词：

D O I：

10.1007/BF01388144

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new method for the assay of the enzyme converting anhydrotetracycline into dehydrotetracycline is described. The enzyme activity increases sharply during the growth phase and reaches its maximum at the beginning of the production phase; it is depressed when the concentration of inorganic phosphate in the cultivation medium is increased. © 1979 Kluwer Academic Publishers.

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页码：177 / 182

页数：6

相关论文

共 11 条

[1] ALTERNATE PATHWAYS OF MALONYLCOA FORMATION IN STREPTOMYCES-AUREOFACIENS [J].

BEHAL, V ;

JECHOVA, V ;

VANEK, Z ;

HOSTALEK, Z .

PHYTOCHEMISTRY, 1977, 16 (03) :347-350

[2] REGULATION OF BIOSYNTHESIS OF SECONDARY METABOLITES .12. ACETYLCOA CARBOXYLASE IN STREPTOMYCES-AUREOFACIENS [J].

BEHAL, V ;

VANEK, Z .

FOLIA MICROBIOLOGICA, 1970, 15 (05) :354-&

[3] RELATIONSHIP BETWEEN CARBOHYDRATE METABOLISM OF STREPTOMYCES AUREOFACIENS + BIOSYNTHESIS OF CHLORTETRACYCLINE .I. EFFECT OF INTERRUPTED AERATION INORGANIC PHOSPHATE + BENZYL THIOCYANATE ON CHLORTETRACYCLINE BIOSYNTHESIS [J].

HOSTALEK, Z .

FOLIA MICROBIOLOGICA, 1964, 9 (02) :78-&

[4] 2 NEW TETRACYCLINE-RELATED COMPOUNDS - 7-CHLORO-5A(11A)-DEHYDROTETRACYCLINE AND 5A-EPI-TETRACYCLINE - A NEW ROUTE TO TETRACYCLINE [J].

MCCORMICK, JRD ;

MILLER, PA ;

GROWICH, JA ;

SJOLANDER, NO ;

DOERSCHUK, AP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (20) :5572-5573

[5]

MCCORMICK JRD, 1965, BIOGENESIS ANTIBIOTI, P73

[6]

MILLER P. A., 1964, BIOCHEM BIOPHYS RES COMMUN, V16, P285, DOI 10.1016/0006-291X(64)90341-9

[7]

Miller P A, 1975, Methods Enzymol, V43, P606

[8]

Miller P A, 1975, Methods Enzymol, V43, P603

[9] BIOSYNTHESIS OF 5-HYDROXYTETRACYCLINE [J].

MILLER, PA ;

HASH, JH ;

LINCKS, M ;

BOHONOS, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 18 (03) :325-&

[10] DEHYDRATION OF TETRACYCLINE [J].

SCHLECHT, KD ;

FRANK, CW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (02) :352-354