SUNSCREEN PROTECTION AGAINST DRUG-INDUCED PHOTO-TOXICITY IN ANIMAL-MODELS

被引:15
作者
AKIN, FJ
ROSE, AP
CHAMNESS, TW
MARLOWE, E
机构
[1] Department of Pharmacology and Toxicology, Plough Division, Schering-Plough Corporation, Memphis
关键词
D O I
10.1016/0041-008X(79)90244-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Phototoxicity was induced in animal models by photoreactive drugs in order to test sunscreen efficacy. In combination with uv-A irradiation, 8-methoxypsoralen and to a lesser extent chlorpromazine and demeclocycline elicited cutaneous erythema, edema, and ulcerative lesions in mice and guinea pigs. A commercial preparation of 5% para-amino-benzoic acid (PABA) in alcohol with proven effectiveness in preventing normal sunburn failed to protect against phototoxic drug reactions. An experimental, broad-spectrum sunscreen, PL-254-containing esters of PABA and benzophenone-blocked virtually all phototoxic response to all three drugs. Absorbance spectra of the PABA product and of PL-254 in solution and on the skin of hairless mice confirmed that PABA absorbs uv energy primarily in the uv-B range while PL-254 absorbed both uv-A and uv-B radiant energy. The uv absorbance spectra of both products on skin differed significantly from their spectra in solution. © 1979.
引用
收藏
页码:219 / 224
页数:6
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