GLYCINE RECEPTOR IMMUNOREACTIVITY IN RAT AND HUMAN CEREBRAL-CORTEX

被引:56
作者
NAAS, E
ZILLES, K
GNAHN, H
BETZ, H
BECKER, CM
SCHRODER, H
机构
[1] UNIV COLOGNE,INST ANAT 1,JOSEPH STELZMANN STR 9,W-5000 COLOGNE 41,GERMANY
[2] TECH UNIV MUNICH,NEUROL KLIN,W-8000 MUNICH 2,GERMANY
[3] UNIV HEIDELBERG,ZENTRUM MOLEK BIOL,W-6900 HEIDELBERG,GERMANY
关键词
CEREBRAL CORTEX; GLYCINE RECEPTOR; NEURONAL INHIBITION; STRYCHNINE;
D O I
10.1016/0006-8993(91)90758-N
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The distribution of the inhibitory glycine receptor was studied in rat and human cerebral cortex using a monoclonal antibody (MAb 4a) directed against the ligand-binding subunit. Significant amounts of glycine receptor antigen were found in forebrain structures such as caudatum and neocortex, although cortical levels were significantly below those seen in spinal cord. Immunohistochemically, glycine receptors were preferentially localized to the apical dendrites of pyramidal neurons in layers III and V. Ultrastructurally, these sites corresponded to synaptic neuronal contacts. Immunoreactivity was found in neuronal perikarya, dendrites and postsynaptic membranes which may correspond to sites of intracellular synthesis, transport and membrane incorporation of the glycine receptor. These immunological data corroborate previous pharmacological studies suggesting the existence of glycinergic transmission in mammalian cerebral cortex.
引用
收藏
页码:139 / 146
页数:8
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