SEVERE COGNITIVE IMPAIRMENT IN ELDERLY SCHIZOPHRENIC-PATIENTS - A CLINICOPATHOLOGICAL STUDY

被引：95

作者：

PUROHIT, DP ^{[1
]}

DAVIDSON, M ^{[1
]}

PERL, DP ^{[1
]}

POWCHIK, P ^{[1
]}

HAROUTUNIAN, VH ^{[1
]}

BIERER, LM ^{[1
]}

MCCRYSTAL, J ^{[1
]}

LOSONCZY, M ^{[1
]}

DAVIS, KL ^{[1
]}

机构：

[1] MT SINAI MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10029

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 04期

关键词：

SCHIZOPHRENIA; COGNITION; ELDERLY;

D O I：

10.1016/0006-3223(93)90291-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The severe cognitive impairment that affects many of the elderly schizophrenic patients could represent the outcome of schizophrenia in old age for the very severe and chronically ill patients or may be the result of lengthy institutionalization and somatic treatment. Alternatively, it could be due to the presence of concurrent dementing disorders, such as Alzheimer's disease (AD) or multi-infarct dementia. Using an identical neuropathological protocol, brain specimens from schizophrenic patients who showed evidence of severe cognitive impairment were compared with 12 age-matched control cases and the same number of age-matched cases of neuropathologically confirmed patients with AD. Despite their relatively advanced age (mean age 77.1 years +/- 2.8), none of the schizophrenia cases showed sufficient degree of senile plaques and neurofibrillary tangle formations to confirm a diagnosis of AD. Other neurodegenerative disorders associated with dementia were also not identified. These studies suggest that alternative explanations need to be sought for the severe cognitive impairment commonly encountered in elderly schizophrenic patients.

引用

页码：255 / 260

页数：6

共 14 条

[1] AGE DISORIENTATION IN CHRONIC-SCHIZOPHRENIA IS NOT ASSOCIATED WITH PRE-MORBID INTELLECTUAL IMPAIRMENT OR PAST PHYSICAL TREATMENT [J].