HYPOGLYCEMIA AND HYPERINSULINEMIA IN RODENT MODELS OF SEVERE MALARIA INFECTION

被引：50

作者：

ELASED, K ^{[1
]}

PLAYFAIR, JHL ^{[1
]}

机构：

[1] UCL, SCH MED, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.62.11.5157-5160.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in association with hyperinsulinemia. Supernatants of lethal P. yoelii incubated overnight induced hypoglycemia and hyperinsulinemia in normal mice. In murine malaria, hypoglycemia may be largely secondary to increased insulin secretion.

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页码：5157 / 5160

页数：4

相关论文

共 22 条

[1]

BATE CAW, 1992, IMMUNOLOGY, V75, P129

[2] METABOLIC DISTURBANCES IN PLASMODIUM-COATNEYI-INFECTED RHESUS-MONKEYS [J].

DAVIS, TME ;

BROWN, AE ;

SMITH, CD .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1993, 23 (05) :557-563

[3] TUMOR NECROSIS FACTOR ENHANCES GLUCOSE-UPTAKE BY PERIPHERAL-TISSUES [J].

EVANS, DA ;

JACOBS, DO ;

WILMORE, DW .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (05) :R1182-R1189

[4]

FEINSTEIN R, 1993, J BIOL CHEM, V268, P26055

[5]

FULTON J. D., 1939, ANN TROP MED AND PARASITOL, V33, P217

[6] TUMOR NECROSIS FACTOR AND DISEASE SEVERITY IN CHILDREN WITH FALCIPARUM-MALARIA [J].

GRAU, GE ;

TAYLOR, TE ;

MOLYNEUX, ME ;

WIRIMA, JJ ;

VASSALLI, P ;

HOMMEL, M ;

LAMBERT, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (24) :1586-1591

[7] IMMUNOASSAY OF INSULIN WITH INSULIN-ANTIBODY PRECIPITATE [J].

HALES, CN ;

RANDLE, PJ .

BIOCHEMICAL JOURNAL, 1963, 88 (01) :137-&

[8] QUININE AND THE STIMULUS-SECRETION COUPLING IN PANCREATIC BETA-CELLS - GLUCOSE-LIKE EFFECTS ON POTASSIUM PERMEABILITY AND INSULIN RELEASE [J].

HENQUIN, JC .

ENDOCRINOLOGY, 1982, 110 (04) :1325-1332

[9] PLASMODIUM-BERGHEI - LACTIC-ACIDOSIS AND HYPOGLYCEMIA IN A RODENT MODEL OF SEVERE MALARIA - EFFECTS OF GLUCOSE, QUININE, AND DICHLOROACETATE [J].

HOLLOWAY, PAH ;

KRISHNA, S ;

WHITE, NJ .

EXPERIMENTAL PARASITOLOGY, 1991, 72 (02) :123-133

[10] QUININE AND SEVERE FALCIPARUM-MALARIA IN LATE PREGNANCY [J].

LOOAREESUWAN, S ;

WHITE, NJ ;

KARBWANG, J ;

TURNER, RC ;

PHILLIPS, RE ;

KIETINUN, S ;

RACKOW, C ;

WARRELL, DA .

LANCET, 1985, 2 (8445) :4-8