HYPOGLYCEMIA AND HYPERINSULINEMIA IN RODENT MODELS OF SEVERE MALARIA INFECTION

被引:50
作者
ELASED, K [1 ]
PLAYFAIR, JHL [1 ]
机构
[1] UCL, SCH MED, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1128/IAI.62.11.5157-5160.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in association with hyperinsulinemia. Supernatants of lethal P. yoelii incubated overnight induced hypoglycemia and hyperinsulinemia in normal mice. In murine malaria, hypoglycemia may be largely secondary to increased insulin secretion.
引用
收藏
页码:5157 / 5160
页数:4
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