SYNTHESIS OF 5-TETHERED CARBORANE-CONTAINING PYRIMIDINE NUCLEOSIDES AS POTENTIAL AGENTS FOR DNA INCORPORATION

被引：32

作者：

RONG, FG ^{[1
]}

SOLOWAY, AH ^{[1
]}

机构：

[1] OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 09期

关键词：

D O I：

10.1080/15257779408010680

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several 5-substituted-2'-deoxyuridines have been prepared in which the carborane moiety is attached at the terminus of a flexible hydrocarbon chain containing an ester linkage. These boron moieties as the B-10 enriched compounds have potentiality for use in the treatment of cancer by means of boron neutron capture therapy. A convenient synthetic route, in high yield, has been developed for the preparation of these 5-tethered carborane-containing pyrimidine nucleosides.

引用

页码：2021 / 2034

页数：14

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