UPTAKE OF AMINO ACIDS BY MOUSE PANCREAS IN VITRO .4. ROLE OF EXCHANGE DIFFUSION

1. 1. The phenomenon of exchange diffusion occurs in mouse pancreas and may lead to a threefold increment in the flux of certain amino acids. 2. 2. The ability of various amino acids to exchange is similar to that observed in other tissues and appears to be independent of whether the amino acid is intra- or extracellular. 3. 3. The exchange diffusion process is independent of the presence of cations, is characterized by a molar influx to efflux ratio which approaches 1:1 and has a half maximum value at a concentration which is equal to the Km value for transport. 4. 4. Interaction between amino acids can occur during exchange diffusion in mouse pancreas. © 1969.