OROSOMUCOID (ORM) TYPING BY ISOELECTRIC-FOCUSING - AN ANALYSIS OF ORM HAPLOTYPES

被引：13

作者：

YUASA, I

UMETSU, K

SUENAGA, K

IHA, M

HIRATA, H

IKEBUCHI, J

机构：

[1] YAMAGATA UNIV, SCH MED, DEPT FORENS MED, YAMAGATA 990, JAPAN

[2] YAMAGUCHI RED CROSS HOSP & BLOOD CTR, YAMAGUCHI, JAPAN

[3] OKINAWA RED CROSS BLOOD CTR, NAHA, JAPAN

来源：

HUMAN HEREDITY | 1990年 / 40卷 / 05期

关键词：

!sub]α1[!/sub]-Acid glycoprotein; Genetic polymorphism; Haplotypes; Japanese population; Orosomucoid;

D O I：

10.1159/000153943

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new separator isoelectric focusing method for typing of orosomucoid (ORM) was developed. This method provided a superior resolution of ORM patterns: two close bands of ORM1*5.2 products were clearly separated. A total of 364 subjects from Okinawa (Japan) were classified into 21 ORM phenotypes determined by 6 ORM I and 7 ORM2 alleles including a polymorphic silent allele, ORM2*QO. and 2 new rare variants, 0RM2*18 and ORM2*19. These phenotypes were also explained by 12 ORM haplotypes, half of which were polymorphic. © 1990 S. Karger AG, Basel.

引用

页码：267 / 271

页数：5

共 22 条

[1] STRUCTURE OF THE HUMAN ALPHA-1-ACID GLYCOPROTEIN GENE - SEQUENCE HOMOLOGY WITH OTHER HUMAN ACUTE PHASE PROTEIN GENES [J].