GLUCAGON-LIKE PEPTIDE-1 (7-36)-NH2 - A PHYSIOLOGICAL INHIBITOR OF GASTRIC-ACID SECRETION IN MAN

被引：84

作者：

OHALLORAN, DJ ^{[1
]}

NIKOU, GC ^{[1
]}

KREYMANN, B ^{[1
]}

GHATEI, MA ^{[1
]}

BLOOM, SR ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,DU CANE RD,LONDON W12 0HS,ENGLAND

来源：

JOURNAL OF ENDOCRINOLOGY | 1990年 / 126卷 / 01期

关键词：

D O I：

10.1677/joe.0.1260169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon-like peptide (GLP)-1 (7-36)-NH2 is a peptide found in the mucosal endocrine cells of the intestine, and plasma levels of GLP-1 (7-36)-NH2 immunoreactivity show a rise after the ingestion of a fat or mixed-component meal. We investigated the effects of physiological infusion of GLP-1 (7-36)-NH2 on a submaximal gastric acid secretion in healthy volunteers at a rate known to mimic the observed postprandial rise in plasma concentrations. Corrected gastric acid output decreased to less than 50% and volume output to 33% of stimulated values. After the infusion, the secretion of gastric acid recovered immediately to preinhibition values. These results suggest a novel role for GLP-1 (7-36)-NH2 as a physiological inhibitor of gastric acid secretion in man.

引用

页码：169 / 173

页数：5

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