INTERLEUKIN-1-BETA AND TUMOR-NECROSIS-FACTOR-ALPHA STIMULATE THE RELEASE OF GONADOTROPIN-RELEASING-HORMONE AND INTERLEUKIN-6 BY PRIMARY CULTURED RAT HYPOTHALAMIC CELLS

被引：30

作者：

YAMAGUCHI, M ^{[1
]}

YOSHIMOTO, Y ^{[1
]}

KOMURA, H ^{[1
]}

KOIKE, K ^{[1
]}

MATSUZAKI, N ^{[1
]}

HIROTA, K ^{[1
]}

MIYAKE, A ^{[1
]}

TANIZAWA, O ^{[1
]}

机构：

[1] OSAKA UNIV, SCH MED, DEPT OBSTET & GYNECOL, OSAKA, JAPAN

来源：

ACTA ENDOCRINOLOGICA | 1990年 / 123卷 / 04期

关键词：

D O I：

10.1530/acta.0.1230476

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The abilities of recombinant human interleukin 1β and tumour necrosis factor α to induce release of GnRH and interleukin 6 from primary culture of rat hypothalamic cells were examined. The effect of estradiol on the release of interleukin 6 by these cells was also tested. Both interleukin 1β and tumour necrosis factor α caused significant stimulation of GnRH secretion from the hypothalamic cells within 5 min. The hypothalamic cells secreted interleukin 6 spontaneously, and their secretion over 24 h was stimulated dose-dependently by interleukin 1β, tumour necrosis factor α and estradiol. These results suggest that interleukin 1β and tumour necrosis factor α stimulate the secretions of GnRH and interleukin 6 in the hypothalamus, and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus.

引用

页码：476 / 480

页数：5

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